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Indications
This medication is used to treat nausea and vomiting caused by pregnancy in women who do not respond to other treatments.
Pharmacology
Doxylamine Succinate is an antihistamine that squares Histamine (H1) receptor. It can cross the blood-brain boundary and contains a tall liking for H1 receptors within the brain that squares H1 receptors. It too diminishes the activity of histamine at the H1 receptor by repressing both the vestibular framework & Muscarinic receptor. It influences the vestibular framework & diminishes the incitement of the heaving center. Its muscarinic receptor inhibition may also play a part in antihistamine antiemetic action. Pyridoxine Hydrochloride may be a vitamin B6 analog. It is utilized to avoid sickness and spewing due to its antiemetic properties.
Dosage & Administration
Interaction
Women who are taking monoamine oxidase inhibitors (MAOIs), which prolong and intensify the adverse central nervous system effects (anticholinergic effects) of antihistamines, should not take Doxylamine Succinate & Pyridoxine Hydrochloride. Alcohol and other CNS depressants (such as hypnotic sedatives and tranquilizers) should not be taken together with Doxylamine Succinate.
Contraindications
In women who have any of the following conditions, Doxylamine Succinate & Pyridoxine Hydrochloride is not recommended:
Monoamine oxidase (MAO) inhibitors intensify and prolong the adverse central nervous system effects of Doxylamine Succinate, other ethanolamine derivative antihistamines, Pyridoxine Hydrochloride, or any inactive ingredient in the formulation.
Side Effects
Pregnancy & Lactation
A is the pregnancy category. This medication is used to treat nausea and vomiting caused by pregnancy in women who do not respond to other treatments. Breast milk excretes both Doxylamine Succinate and Pyridoxine Hydrochloride. As a result, caution should be used when breastfeeding.
Precautions & Warnings
Doxylamine Succinate & Pyridoxine Hydrochloride may cause lethargy due to the anticholinergic properties of Doxylamine Succinate, an antihistamine. Ladies ought to maintain a strategic distance from locks in exercises, such as driving or working overwhelming apparatus, whereas utilizing Doxylamine Succinate & Pyridoxine Hydrochloride. Doxylamine Succinate & Pyridoxine Hydrochloride utilization isn't suggested in the event that a lady is concurrently utilizing central apprehensive framework (CNS) depressants counting alcohol.
Doxylamine Succinate & Pyridoxine Hydrochloride has anticholinergic properties and, so, ought to be utilized with caution in ladies with asthma, expanded intraocular weight, contract point glaucoma, stenosing peptic ulcer, pyloroduodenal hindrance or urinary bladder-neck hindrance.
Storage Conditions
Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.
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